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The 19th century pathologist Rudolf Virchow was distinctive in his emphasis on multifocal and transdisciplinary thinking about the determinants of health and disease. Most famously, he wrote a ground-breaking report for the Prussian Government on the 1847–48 typhus outbreak in the region of Upper Silesia, advocating free and unlimited democracy as the single most important principle in addressing the epidemic.

Medicine as social science: Rudolf Virchow on the typhus epidemic in Upper Silesia.